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Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

NCT05279898 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-11-26

Study results available
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Summary

In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to:

1. reduce the incidence of perioperative neurocognitive dysfunction in cardiac surgical patients
2. ensure hemodynamic stability and decrease use of vasopressors in the operating rooms
3. reduce pain and opioid consumption postoperatively

Conditions

  • Postoperative Delirium
  • Hemodynamic Instability
  • Pain
  • Neurocognitive Dysfunction

Interventions

DEVICE

EEG Monitoring

Perioperative monitoring, MMGA guided by EEG for intervention group

DRUG

Ropivacaine

Intraoperative bilateral PIFB block with 20 mL of 0.2% Ropivicaine on either side of the sternum after anesthetic induction but before surgical incision (total of 40mL) PIFB on postoperative day 1 (provided they are extubated or getting ready to be extubated) to help with mobilization (for intervention group)

DRUG

Ketamine

Intraoperative infusion

DRUG

Remifentanil

Intraoperative infusion

DRUG

Dexmedetomidine

Intraoperative infusion

DRUG

Rocuronium

Intraoperative intermittent bolus

DRUG

Propofol

Intraoperative infusion

Sponsors & Collaborators

Principal Investigators

  • Balachundhar Subramaniam, MD,MPH,FASA · Beth Israel Deaconess Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-28
Primary Completion
2024-06-30
Completion
2024-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05279898 on ClinicalTrials.gov