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Memory Modulation by Pain During Anesthesia

NCT02515890 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2020-07-01

Study results available
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Summary

The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.

Conditions

  • Amnesia
  • Pain
  • Anesthesia

Interventions

DRUG

Dexmedetomidine

Selected subjects received this drug during a portion of the study

DRUG

Midazolam

Selected subjects received this drug during a portion of the study

DEVICE

Peripheral nerve stimulation

Experimental acute pain stimulus was delivered using a nerve stimulator. These painful shocks were paired randomly with some of the auditory experimental cues.

DRUG

Ketamine

Selected subjects received this drug during a portion of the study

Sponsors & Collaborators

  • Foundation for Anesthesia Education and Research

    collaborator OTHER

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Keith M Vogt, MD, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
39 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-11-19
Primary Completion
2018-12-12
Completion
2018-12-12
FDA Drug
Yes
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02515890 on ClinicalTrials.gov