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Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers

NCT05279053 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 58

Last updated 2026-03-20

Study results available
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Summary

The proposed study evaluated sex differences in glutamate (Glu), with a focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, as well as how it is influenced by sex (males vs. females), smoking state (overnight abstinent vs. sated), and circulating ovarian hormones (estrogen and progesterone) in women. Glu was measured in the entire brain with special focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, all of which have been implicated in tobacco withdrawal, using an echo-planar spectroscopic imaging (EPSI) variant of magnetic resonance spectroscopy (MRS). Serum ovarian hormones (estrogen and progesterone) were measured for female participants to determine relationships between brain Glu and this hormone. Glu was be measured in smokers after overnight (\~12 h) abstinence and after participants smoked the first cigarette of the day.

Conditions

  • Sex
  • Cigarette Smoking

Interventions

BEHAVIORAL

Abstinence and Smoking

Participants came to the lab after overnight abstinence from smoking and smoked their first cigarette of the day.

Sponsors & Collaborators

Principal Investigators

  • Edythe London, PhD · University of California, Los Angeles

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2023-03-31
Completion
2023-03-31

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05279053 on ClinicalTrials.gov