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Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)

NCT05246813 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2026-03-25

No results posted yet for this study

Summary

Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.

Conditions

  • Osteoporosis
  • Osteoarthritis, Hip
  • Hip Fractures
  • Clonal Hematopoiesis of Indeterminate Potential
  • Aging

Interventions

OTHER

Blood and bone marrow cell collection

Collection of blood and bone marrow

Sponsors & Collaborators

  • Université Catholique de Louvain

    collaborator OTHER

  • Imelda Hospital, Bonheiden

    lead OTHER

Principal Investigators

  • Nick Van Gastel, PhD · de Duve Institute

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-11
Primary Completion
2028-12-31
Completion
2030-12-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05246813 on ClinicalTrials.gov