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Myeloproliferative Neoplasms: an In-depth Case-control Study

NCT01831635 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 234

Last updated 2024-01-08

Study results available
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Summary

There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control studies that have investigated a wide range of potential medical, environmental and occupational risk factors. However, these studies have been limited by a wide variation in case definition and small sample sizes limiting the potential to detect modest risk differences between cases and controls. The research group propose an exploratory case-control study of 100 patients with classic MPNs and 200 controls to determine the optimal methods for roll out of this study to a multi-centred UK-based case-control study that will investigate the aetiology of MPN subtypes. The objectives of the study are to evaluate recruitment procedures, response rates and the development of a telephone administered questionnaire. The findings of this exploratory study will form the basis of a protocol for a large United Kingdom (UK)-wide case-control study of MPNs.

Conditions

Interventions

OTHER

Methodological pens

Randomisation of branded pen, non-branded pen and no pen

OTHER

Methodological compensation

Randomisation of a £10 monetary reimbursement for expenses on completion of the study

OTHER

Methodological trolley tokens

Trolley tokens to be randomly assigned to half of cases and General Practice controls.

Sponsors & Collaborators

  • University Hospital Southampton NHS Foundation Trust

    collaborator OTHER

  • University of Manchester

    collaborator OTHER

  • Western Australian Institute for Medical Research

    collaborator OTHER

  • Mayo Clinic

    collaborator OTHER

  • Queen's University, Belfast

    lead OTHER

Principal Investigators

  • Lesley A Anderson, PhD · Queen's University, Belfast

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-04-30
Primary Completion
2014-07-31
Completion
2015-06-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01831635 on ClinicalTrials.gov