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eMESH Struct. 2022-23

NCT05202938 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2023-07-20

No results posted yet for this study

Summary

A flexible energy metabolism matched with the contractile needs of the muscle is essential to a normal heart. Loss of metabolic flexibility and cardiac systolic efficiency coexist in Sepsis-induced Myocardial Dysfunction (SIMD), a phenomenon attributed to mitochondrial dysfunction and mishandling of energy substrates. Cardiac positron emission tomography (PET) could allow to quantify non invasively the selection of energy substrates by the hearts in sepsis and will be associated in parallel with functional status (ultrasound cardiography), injury biomarkers, apelinergic and metabolomic blood profiles. Comparisons will be performed between septic and acute on chronic heart failures, with or without systolic dysfunction.

Conditions

Interventions

DIAGNOSTIC_TEST

ultrasound cardiography

Ultrasound to check heart functions and systolic ejection fraction.

DIAGNOSTIC_TEST

FDG PET scan

FDG venous injection and positron emission tomography scan.

DIAGNOSTIC_TEST

Palmitate PET scan

C11-Palmitate venous injection and positron emission tomography scan.

DIAGNOSTIC_TEST

Acetate PET scan

C11-Acetate venous injection and positron emission tomography scan.

DIAGNOSTIC_TEST

Blood sampling

Collecting 20ml of venous blood.

Sponsors & Collaborators

  • Centre de recherche du Centre hospitalier universitaire de Sherbrooke

    lead OTHER

Principal Investigators

  • Olivier Lesur, MD PhD · Centre de recherche du Centre hospitalier universitaire de Sherbrooke

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-21
Primary Completion
2023-12-21
Completion
2024-07-21

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05202938 on ClinicalTrials.gov