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Microvascular Injury and Distal Thrombosis in COVID-19

NCT04990505 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2022-03-23

No results posted yet for this study

Summary

Investigators aimed to better understand the pathophysiology of SARS-CoV-2 pneumonia in non-critically ill hospitalized patients secondarily presenting with clinical deterioration and increase in oxygen requirement

Conditions

Interventions

DIAGNOSTIC_TEST

lung ventilation/perfusion scintigraphy

Chest CT-scan will be performed with blocked inspiration. Lung ventilation/perfusion scintigraphy imaging will be performed within 24hrs after CT pulmonary angiography, 410MBq of Technegas will be inhaled by patients and ventilation tomography performed thereafter. Then, 185MBq 99mTc-macroaggegates will be injected intravenously followed by the perfusion tomography. A combined CT acquisition will be performed. The day following lung ventilation/perfusion scintigraphy, 740MBq of Tc99m labeled albumin will be intravenously administered. Cardiac gated-blood-pool scintigraphy will be then performed in best septal left anterior oblique and left profile according to specific parameters. 45-60 min after injection, a non-gated tomographic acquisition over the lungs will be done, with the same parameters than for PS SPECT, resulting in a late albumin acquisition.

Sponsors & Collaborators

  • Centre Hospitalier Princesse Grace

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-22
Primary Completion
2021-10-18
Completion
2022-02-28

Countries

  • Monaco

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04990505 on ClinicalTrials.gov