Chronic heart failure is a syndrome in which the heart cannot fill and/or pump blood effectively enough to meet the body's needs. It typically presents with dyspnea, fatigue, and edema and requires long-term medical management.
China's 12th national Volume-Based Procurement round places RMB 60 billion across 65 drug varieties, accelerating generics and biosimilars substitution. Separately, Genialis launched BioBridge to help translate Chinese oncology trial results into Western development programs, as Chinese out-licensing hit $137.7 billion in 2025.
mRNA medicine and spatiotemporal drug delivery systems are expanding options for cardiovascular disease. The sources describe preclinical proof-of-concept, clinical trials and programmable cardiac repair platforms.
The FDA has expanded approval of GSK's Arexvy RSV vaccine to include adults aged 18 to 49 years at increased risk for lower respiratory tract disease, based on phase 3b trial data showing noninferior immune response.
AstraZeneca has completed a Phase IIb heart failure trial for AZD5462, finished a real-world breast cancer study in Brazil, and is recruiting for an observational COPD study in heart clinic patients.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07734831 |
TELEREHAB-BR: Cardiovascular Rehabilitation Models Trial |
NOT_YET_RECRUITING | NA |
| NCT07717749 |
A Study to Evaluate the Safety, Pharmacokinetics of AD-118 and AD-1181 in Healthy Adult Subjects |
NOT_YET_RECRUITING | PHASE1 |
| NCT07697365 |
Vericiguat and Exercise Hemodynamics in Patients With HFrEF |
COMPLETED | |
| NCT07686536 |
A CSM-Based Volume Management Program for Chronic Heart Failure |
NOT_YET_RECRUITING | NA |
| NCT07650474 |
Mobile-Based Telemedicine and Health-Related Quality of Life Among Patients With Chronic Heart Failure (MOBILE-HF) |
RECRUITING | NA |
| NCT07647848 |
Therapy Adjustment and IndividuaLized Response With Biomarker Observation in ReaL-world Heart Failure |
NOT_YET_RECRUITING | |
| NCT07628777 |
Fecal Microbiota Transplantation for Elderly Patients With HFpEF: A Randomized Controlled Trial |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07599345 |
Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims Data |
COMPLETED | |
| NCT07599293 |
Emulation of the EMPEROR-Preserved Trial Using Healthcare Claims Data |
COMPLETED | |
| NCT07561866 |
Prognostic Impact of Diabetes and Weight Variability in Telemonitored Heart Failure |
COMPLETED |
