Chronic heart failure is a syndrome in which the heart cannot fill and/or pump blood effectively enough to meet the body's needs. It typically presents with dyspnea, fatigue, and edema and requires long-term medical management.
mRNA medicine and spatiotemporal drug delivery systems are expanding options for cardiovascular disease. The sources describe preclinical proof-of-concept, clinical trials and programmable cardiac repair platforms.
The FDA has expanded approval of GSK's Arexvy RSV vaccine to include adults aged 18 to 49 years at increased risk for lower respiratory tract disease, based on phase 3b trial data showing noninferior immune response.
AstraZeneca has completed a Phase IIb heart failure trial for AZD5462, finished a real-world breast cancer study in Brazil, and is recruiting for an observational COPD study in heart clinic patients.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07599345 |
Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims Data |
ACTIVE_NOT_RECRUITING | |
| NCT07599293 |
Emulation of the EMPEROR-Preserved Trial Using Healthcare Claims Data |
ACTIVE_NOT_RECRUITING | |
| NCT07561866 |
Prognostic Impact of Diabetes and Weight Variability in Telemonitored Heart Failure |
COMPLETED | |
| NCT07490054 |
Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure |
RECRUITING | PHASE1 |
| NCT07476157 |
A Study to Evaluate the Safety and Pharmacokinetics of AD-118 and AD-1181 in Healthy Adult Subjects |
NOT_YET_RECRUITING | PHASE1 |
| NCT07443969 |
Pre-Symptomatic Detection of Impending Decompensation in Heart Failure Through Voice Data |
ACTIVE_NOT_RECRUITING | |
| NCT07434193 |
Biventricular or Left Bundle Branch Pacing to Assess the Effect of Cardiac Resynchronization Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation |
RECRUITING | NA |
| NCT07405944 |
Vericiguat and Reverse Remodeling Indices in Heart Failure |
RECRUITING | PHASE4 |
| NCT07379840 |
A Study to Learn More About How Safe Finerenone is and How Well it Works in Adults With Chronic Heart Failure in South Korea |
RECRUITING | |
| NCT07369141 |
PREcision meDICine in Treatment in CardioVascular Disease |
WITHDRAWN | NA |
