Effectiveness of Theobromine Toothpaste

Summary

Since plaque control forms the basis for caries prevention, the type of toothpaste and its constituents becomes more important.

Toothpaste containing fluoride are widely popular and fluorides have been historically reported to have effects against dental caries. However, the fluoride safe doses are still discussed ,because fluoride has toxicity and causing fluorosis.

The aim of the current research is to find alternative agent that can be used without side effects.

Conditions

• Dental Plaque
• Dental Care

Interventions

OTHER

Evaluation of the effectiveness of low- fluoridated toothpaste.

Children will be given low- fluoridated toothpaste, plaque score in groups will be assess pre given toothpaste in baseline,aweek,2week,and after 3weeks by using the TMQHPI for both buccal and lingual surface. Gingivalitis will be assess pre given toothpaste,aweek,2weeks,and after 3weeks by using gingival index (loe and silness).

OTHER

Evaluation of the effectiveness of fluoridated toothpaste.

Children will be given e fluoridated toothpaste, plaque score in groups will be assess pre given toothpaste in baseline,aweek,2week,and after 3weeks by using the TMQHPI for both buccal and lingual surface. Gingivalitis will be assess pre given toothpaste,aweek,2weeks,and after 3weeks by using gingival index (loe and silness).

OTHER

Evaluation of the effectiveness of theobromine toothpaste (2%) toothpaste.

Children will be given theobromine toothpaste(2%),plaque score in groups will be assess pre given toothpaste in baseline,aweek,2week,and after 3weeks by using the TMQHPI for both buccal and lingual surface. Gingivalitis will be assess pre given toothpaste,aweek,2weeks,and after 3weeks by using gingival index (loe and silness).

OTHER

Evaluation of the effectiveness of theobromine toothpaste(4%) toothpaste.

Children will be given theobromine toothpaste(4%),plaque score in groups will be assess pre given toothpaste in baseline,aweek,2week,and after 3weeks by using the TMQHPI for both buccal and lingual surface. Gingivalitis will be assess pre given toothpaste,aweek,2weeks,and after 3weeks by using gingival index (loe and silness).

Sponsors & Collaborators

• Damascus University

  lead OTHER

Principal Investigators

• Nour M Zaaweet, DDS · MSc student in Pedodontics, University of Damascus

• Ettihad A Abo-Arraj, Phd · Professor of Pedodontics, Department of Pedodontics, University of Damascus

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

6 Years

Max Age

9 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-09-25

Primary Completion

2021-11-01

Completion

2021-12-01

Countries

• Syria

Study Locations