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Brain Circuitry Analysis in Bipolar Disorder

NCT05186077 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 26

Last updated 2025-10-09

No results posted yet for this study

Summary

The goal of this cross-sectional study is to use diffusion-weighted imaging based tractography (DWT) to assess white matter (WM) pathways in treatment-refractory bipolar disorder (REF-BD) and treatment responsive bipolar disorder (RSP-BD) subjects compared to healthy controls (HCs). This project will include a prospective controlled trial to include 50 subjects with REF-BD, 50 patients RSP-BD and 50 healthy volunteers.

Conditions

Interventions

OTHER

Magnetic Resonance Imaging

Imaging data for research purposes (high-resolution T1 structural and DWI MRI) will be acquired

OTHER

Psychiatric testing

Subjects will be evaluated using psychiatric assessments

OTHER

Eye-Tracking

Eye-tracking assessments will be done to biases toward positive and negative stimuli including images of neutral, fearful/threatening, sad, and happy.

OTHER

Neuropsychology Evaluation

The neuropsychology evaluation will measure verbal learning/memory, attention/working memory, psychomotor speed, verbal fluency/processing speed, and executive function

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • University Hospitals Cleveland Medical Center

    collaborator OTHER

  • Jennifer Sweet

    lead OTHER

Principal Investigators

  • Jennifer Sweet, MD · University Hospitals Cleveland Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-15
Primary Completion
2025-07-31
Completion
2025-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05186077 on ClinicalTrials.gov