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mNGS Versus Blood Culture in FN

NCT05149547 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2021-12-08

No results posted yet for this study

Summary

Blood stream infection (BSI) during febrile neutropenia (FN) is a lethal complication, while confirmed diagnosis via blood culture is usually with low sensitivity and time delay. The new technique of metagenome next generation sequencing (mNGS) has the potential of early and more accurate detection of pathogens. However, this technique has not been well validated for BSI diagnosis in patients with hematological disease. Therefore, we designed a prospective multicenter study to compare the diagnosis performance in BSI.

Conditions

Interventions

DIAGNOSTIC_TEST

blood culture versus mNGS detection

peripheral 4ml for mNGS detection

Sponsors & Collaborators

  • Peking University First Hospital

    collaborator OTHER

  • Peking University International Hospital

    collaborator OTHER

  • Hebei Yanda Ludaopei Hospital

    collaborator OTHER

  • Peking University People's Hospital

    lead OTHER

Principal Investigators

  • YUQIAN SUN, MD · Peiking University People's Hospital

Eligibility

Min Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-15
Primary Completion
2022-05-31
Completion
2022-08-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05149547 on ClinicalTrials.gov