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Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

NCT03252028 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2017-08-21

No results posted yet for this study

Summary

Background: Due to anatomical restrictions, the inflammatory response to intra-cerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage. However, diagnosing meningitis in patients after neurosurgery is complicated, due to brain tissue damage and changes in cerebrospinal fluid (CSF) caused by surgery. Hepatocyte growth factor (HGF) is a local, acute-phase protein. Previous studies on community-acquired septic meningitis reported high levels of intrathecal-produced HGF.

Aim: The aim of present study is to evaluate a new platform for qualitative determination of HGF in body fluids and revealing the site of injury.

Method: Based on a reverse-methachromacy method, strips are prepared. The surface on the strip changes colour to blue upon contact with HGF.

Plan: CSF, urine and sputum of patients that develop fever post neurosurgery are analysed with the test and the results compared with conventional diagnostic methods.

Clinical value: A rapid, equipment-free test gives the opportunity to identify the infectious focus in the infected organ long before culture results are available.

Conditions

  • Infection, Bacterial
  • Antibiotic Resistant Infection
  • Diagnostic Self Evaluation
  • Meningitis, Bacterial
  • Nosocomial Infection

Sponsors & Collaborators

  • Fariba Nayeri

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-12-02
Primary Completion
2019-12-01
Completion
2020-12-01

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03252028 on ClinicalTrials.gov