Febrile neutropenia is an oncologic emergency defined by fever in the setting of neutropenia, commonly occurring after myelosuppressive cancer therapy. It is associated with high infection risk, potential bacteremia, and rapid clinical deterioration if not treated promptly. Immediate empiric broad-spectrum antibiotics are standard of care.
The antibody-drug conjugate sacituzumab tirumotecan demonstrated significant survival benefits in pretreated EGFR-mutated NSCLC, with median overall survival of 20.0 months versus 13.5 months for docetaxel. The treatment also showed superior progression-free survival and objective response rates with a favorable safety profile compared to chemotherapy.
The FDA approved pembrolizumab (Keytruda) and Keytruda Qlex plus paclitaxel, with or without bevacizumab, for adults with PD-L1+ platinum-resistant ovarian carcinoma based on Phase 3 trial data showing improved survival outcomes.
The FDA has approved Filkri (filgrastim-laha), a biosimilar to Neupogen, for cancer patients at risk of infection due to chemotherapy and other indications. The approval marks Accord BioPharma's sixth biosimilar product.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07277387 |
Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia |
NOT_YET_RECRUITING | |
| NCT07204522 |
Efficacy of Empirical Anti-Infective Therapy in Neutropenic Febrile Patients. |
RECRUITING | |
| NCT06988826 |
Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia |
NOT_YET_RECRUITING | PHASE4 |
| NCT06918587 |
A Comparative Evaluation of Pharmacokinetics and Immunogenicity. |
COMPLETED | PHASE1 |
| NCT06787326 |
Effect of the BioFire FilmArray (BCID2) for the Rapid Detection of Bloodstream Infection in Haematologic Patients With Febrile Neutropenia |
ACTIVE_NOT_RECRUITING | |
| NCT06697262 |
Impact of a Telemonitoring Device on the Occurever at Home in Children at Risk of Chemotherapy-Induced Neutropenia |
NOT_YET_RECRUITING | NA |
| NCT06657183 |
ECM and Monitoring w/ Alio Smart Patch in Cancer Pts Receiving Chemotherapy |
RECRUITING | NA |
| NCT06500715 |
Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma |
NOT_YET_RECRUITING | NA |
| NCT06450821 |
PROSpECT-PRIOR-2-CHEMO: PRIOR Dental Intervention Before Chemo to Reduce Chemotherapy Complications |
NOT_YET_RECRUITING | NA |
| NCT06342115 |
Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing Pathogens |
RECRUITING | PHASE4 |
