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EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit

NCT05147636 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 425

Last updated 2025-12-05

No results posted yet for this study

Summary

Extubation in intensive care unit is a risky situation. Its failure is associated with an increase in the duration of mechanical ventilation and high morbidity and mortality.

Our hypothesis is that the extubation procedure associating prior endotracheal aspiration followed by ablation of the intubation probe under the application of a PEEP, would make it possible both to avoid the leakage of secretions towards the lower airways and the alveolar recruitment, compared to extubation with concomitant endotracheal aspiration.

By these mechanisms, this extubation procedure combining prior endotracheal aspiration followed by ablation of the tube under the application of a PEEP, would make it possible to increase the ventilator free days from any mechanical ventilation.

Conditions

  • Extubation in Intensive Care Unit

Interventions

PROCEDURE

Extubation with PEEP

No aspiration within the 3 minutes before extubation and extubation with 10cmH2O PEEP

PROCEDURE

Endotracheal Aspiration

Aspiration during cuff deflation

Sponsors & Collaborators

  • Direction Générale de l'Offre de Soins

    collaborator OTHER_GOV

  • Hospices Civils de Lyon

    collaborator OTHER

  • the EXSUPEEP study was supported by a grant from the French Ministry of Health (MoH-fr)

    collaborator UNKNOWN

  • Centre Hospitalier de Bourg en Bresse

    lead OTHER

Principal Investigators

  • Nicholas SEDILLOT · CH Bourg en Bresse

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-22
Primary Completion
2025-03-19
Completion
2025-03-19

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05147636 on ClinicalTrials.gov