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Atelectasis Formation: Role of Positive Pressure Breathing, Hyperoxia, and Hypobaria

NCT03311347 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2019-05-14

No results posted yet for this study

Summary

The primary aim of this project is to get further knowledge of the physiology of flight atelectasis and its prevention. We seek to: 1) assess whether low levels of positive pressure breathing can prevent atelectasis formation in humans during exposure to hyperoxia and +Gz-accelerations. 2) get further knowledge on the effects of hypobaria on regional ventilation and perfusion.

A secondary aim is to evaluate the effect of anti G-trouser inflation on ventilation and regional perfusion.

Conditions

  • Pulmonary Atelectasis

Interventions

OTHER

+Gz accelerations and positive pressure breathing

Sponsors & Collaborators

  • Uppsala University Hospital

    collaborator OTHER

  • Percy Hospital

    collaborator UNKNOWN

  • Direction Centrale du Service de Santé des Armées

    lead OTHER

Principal Investigators

  • Dominique Felten, MD · Armed Forces Biomedical Research Institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-09-14
Primary Completion
2019-06-30
Completion
2020-01-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03311347 on ClinicalTrials.gov