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Predictors Of Successful Extubation in Critically Ill Patients: Multicentre Observational Study

NCT03185962 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 499

Last updated 2021-01-26

No results posted yet for this study

Summary

Extubation failure can directly worsen patient outcomes. Therefore, the decision to extubate is a critical moment during an intensive care unit (ICU) stay. The decision to extubate is usually made after a weaning readiness test involving spontaneous breathing on a T-piece or low levels of ventilatory assistance. However, extubation failure still occurs in 10 to 20% of patients. The investigators focused on previously reported physiological risk factors, and were able to obtain from common clinical practice: 1) age, 2) underlying cardiovascular disease, 3) underlying respiratory disease or occurrence of pneumonia, 4) rapid shallow breathing index (RSBI), 5) positive fluid balance during the previous 24 hours, 6) the ratio of arterial oxygen partial pressure to fractional inspired oxygen, 7) Glasgow Coma Scale, 8) respiratory tract secretions. The investigators aimed to assess the incidence and risk factors for extubation failure among critically ill patients who passed the 30 min spontaneous breathing test (SBT) using a low level of pressure support (PS) with positive end-expiratory pressure (PEEP), in a prospective multicenter study.

Conditions

  • Intubation
  • Extubation
  • Weaning
  • Mechanical Ventilation
  • Liberation From Mechanical Ventilation
  • Critical Care

Sponsors & Collaborators

  • Osaka University

    lead OTHER

Principal Investigators

  • Yuji Fujino · Department of Anesthesiology and Intensive Care Medicine, Osaka University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-01
Primary Completion
2019-10-31
Completion
2020-08-25

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03185962 on ClinicalTrials.gov