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ANAL PRECANCEROUS LESIONS IN HIGH-RISK PATIENTS.

NCT05060640 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2022-12-12

No results posted yet for this study

Summary

HIV-positive patients, women with a history of genital neoplasia and patients under pharmacologically immunosuppression (e.g. transplanted recipients, Crohn´s disease and Lupus) are a high-risk population for anal human-papillomavirus infection and associated complications, like anal precancerous lesions and anal squamous cell carcinoma. There is a lack of information on the prevalence of anal precancerous detected by routine colonoscopy in this population, by evaluating the squamocolumnar junction (the most susceptible area for lesions) during this procedure. Given, the increasing incidence rates of anal squamous cell carcinoma expected for the next two decades and the increase number of at-risk patients, the possible benefit of routine endoscopy in the diagnosis of anal precancerous lesions needs to be further explored.

Conditions

  • AIN3
  • AIN2
  • HSIL, High Grade Squamous Intraepithelial Lesions

Interventions

PROCEDURE

Detection of anal HSIL in a routine colonoscopy.

Detection of anal HSIL in a routine colonoscopy by using acetic acid and NBI/BLI.

Sponsors & Collaborators

  • University Fernando Pessoa

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-26
Primary Completion
2024-08-31
Completion
2024-08-31

Countries

  • Portugal

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05060640 on ClinicalTrials.gov