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Evaluation of Some Risk Factors Associated With Colorectal Cancer

NCT05170360 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-12-28

No results posted yet for this study

Summary

1. Evaluation of some risk factors (e.g. smoking, heavy metal exposure, and organophosphorus exposure) on CRC.
2. Estimation of KRAS and BRAF genes mutations associated with CRC.
3. Association between different risk factors and gene mutations on different types of CRC.

Conditions

  • Colorectal Neoplasms

Interventions

DIAGNOSTIC_TEST

Assessment of smoking ,heavy metal, organophosphorus exposure and d) Mutational analysis of the KRAS and BRAF genes:

1. Assessment of smoking exposure: Serum cotinine will be measured by using serum cotinine ELISA kits 2. Assessment of heavy metal exposure: Lead and cadmium will be measured using Graphite Tube Atomizer. 3. Assessment of organophosphorus exposure: By measuring pseudocholinesterase level by spectrophotometer 4. Mutational analysis of the KRAS and BRAF genes: the tissue samples will be used to determine the mutation in k-ras and BRAF genes by RCR

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Hayam Z Thabet, prof.DR · Assiut University

  • Heba A. Yassa, prof.DR · Assiut University

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-12-31
Primary Completion
2023-06-30
Completion
2023-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05170360 on ClinicalTrials.gov