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Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension

NCT05059795 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 350

Last updated 2025-09-02

No results posted yet for this study

Summary

In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the mortality associated with fluid overload.

The parameters and methodology used for assessing fluid responsiveness have been studied earlier, but the optimum method is not established. Existing recommendations based on data regarding fluid responsiveness and choice of fluid for resuscitation from intensive care units in general cannot be applied to those with liver disease as the hemodynamic alterations that occur with liver disease, presence of hypoalbuminemia at baseline and presence of cardiac dysfunction interfere with the conventional methods of fluid status assessment, fluid responsiveness as well as the response to different types of resuscitation fluids.

Therefore the investigators attempt to compare various methods to estimate current intravascular volume status of patient which could be helpful in guiding fluid therapy.

Conditions

  • Cirrhosis, Liver
  • Sepsis
  • Acute on Chronic Liver Failure

Interventions

DRUG

Albumin + electrolyte solution

Type of resuscitation fluid, dose and use of inotrope

DIAGNOSTIC_TEST

POCUS guided fluid resuscitation

Conventional goal directed therapy

Sponsors & Collaborators

  • Post Graduate Institute of Medical Education and Research, Chandigarh

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-01
Primary Completion
2025-07-01
Completion
2025-08-10

Countries

  • India

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05059795 on ClinicalTrials.gov