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Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD

NCT05055154 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2021-09-24

No results posted yet for this study

Summary

Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms. Oxidative stress (OS) can induce DNA damage and inhibit DNA repair mechanisms. Very low calorie diet (VLCD) have rapid positive effect on weight loss, glucose homeostasis, insulin resistance, inflammation and OS. The aim of this study is to determine the effect of a three-week VLCD on anthropometric, biochemical and genomic parameters in individuals with BMI ≥ 35kg/m2.

Conditions

Interventions

DEVICE

Very low calorie diet

In hospital patients will eat prepared diet with 567 kcal a day during 3 weeks

Sponsors & Collaborators

  • Institute for Medical Research and Occupational Health

    collaborator UNKNOWN

  • University of Zagreb

    collaborator OTHER

  • Special Hospital for Extended Treatment of Duga Resa

    lead OTHER_GOV

Principal Investigators

  • Mirta Milic, PhD · Institute for Medical Research and Occupational Health

  • Dragan Bozcevic, Doctor · Special Hospital for Extended Treatment of Duga Resa

  • Ana-Marija Domijan, Prof. · University of Zagreb

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-14
Primary Completion
2020-11-03
Completion
2020-11-03

Countries

  • Croatia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05055154 on ClinicalTrials.gov