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Single Cell Leukocyte Landscapes and Cardiovascular Risk in Children With Chronic Kidney Disease

NCT04976010 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2022-02-08

No results posted yet for this study

Summary

Chronic kidney disease (CKD) is associated with an increased cardiovascular mortality. In particular children with early-onset CKD have a lifelong increased risk to suffer from cardiovascular disease (CVD). Therefore, children with CKD deserve our attention. The immune system in children with CKD is disturbed, exhibiting pro-inflammatory features. Therefore, we aim to learn more about the characteristics of the immune system in early-onset CKD. In this project PBMC of pediatric CKD patients and age-matched healthy controls will be analysed and compared using CITE-Seq as a multimodal scRNAseq phenotyping method. All patients will be clinically characterized to integrate cardiovascular and immunological data.

Conditions

Interventions

OTHER

No intervention

There will be no intervention in the separate goups, as this is an observational study

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    lead OTHER

Principal Investigators

  • Dominik Müller, MD · Charite University, Berlin, Germany

Eligibility

Min Age
5 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-17
Primary Completion
2021-11-19
Completion
2021-11-19

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04976010 on ClinicalTrials.gov