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Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human

NCT02745444 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-09-29

No results posted yet for this study

Summary

The key objective of this pilot study is to assess the molecular mechanisms of renal pre-conditioning by a one-week low-calorie diet in humans.

The protective effect of the low-calorie diet and also of the protein-restriction in donor on transplant qualities and functions in receptor will also be investigated.

Analysis of transcriptome, lipidome, metabolome, epigenome, proteome und phosphoproteome through tissue samples as well as blood samples for comparison of low-calorie diet, protein-restriction and no-diet groups.

Conditions

Interventions

DIETARY_SUPPLEMENT

low-calorie formula diet

DIETARY_SUPPLEMENT

protein-restricted diet

Sponsors & Collaborators

  • University of Cologne

    lead OTHER

Principal Investigators

  • Volker Burst, MD · Principal Investigator

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2019-05-17
Completion
2020-05-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02745444 on ClinicalTrials.gov