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The Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study

NCT01046448 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 650

Last updated 2010-01-12

No results posted yet for this study

Summary

Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) morbidity and mortality. Recent studies suggest that pediatric patients with even moderately impaired kidney function may be afflicted with significant early cardiac and vascular abnormalities.

The pathogenesis and the natural course of CV comorbidity in pediatric CKD patients is still elusive. In this multicenter, prospective, observational study the prevalence, degree and progression of CV comorbidity in children will be characterized and related to CKD progression. The morphology and function of the heart and vessels will be monitored by sensitive, non-invasive methods and will be compared with aged matched healthy controls. Multiple potential clinical, anthropometric, biochemical, and pharmacological risk factors will be monitored prospectively and will be related to CV status. Genotyping might identify predisposing genetic factors for progression of CV comorbidity and underlying nephropathies.

Conditions

Sponsors & Collaborators

  • KfH Foundation for Preventive Medicine

    collaborator UNKNOWN

  • German Federal Ministry of Education and Research

    collaborator OTHER_GOV

  • Heidelberg University

    lead OTHER

Principal Investigators

  • Franz Schaefer, MD · Center for Pediatric and Adolescent Medicine, University of Heidelberg, Germany

  • Uwe Querfeld, MD · Klinik für Pädiatrie m.S. Nephrologie, Charite, 13353 Berlin, Germany

Eligibility

Min Age
6 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2014-04-30
Completion
2014-04-30

Countries

  • Austria
  • Belgium
  • Czechia
  • France
  • Germany
  • Hungary
  • Italy
  • Lithuania
  • Poland
  • Portugal
  • Serbia
  • Sweden
  • Switzerland
  • Turkey (Türkiye)
  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01046448 on ClinicalTrials.gov