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Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia

NCT04972318 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 214

Last updated 2024-02-05

No results posted yet for this study

Summary

Randomized Controlled Trial Comparing Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia. The control strategy will be based on ARDSNet approach. The intervention group will receive a different ventilatory strategy based on positive end-expiratory pressure tailored according to compliance and limited driving pressure.

Conditions

  • Community-acquired Pneumonia
  • Acute Respiratory Distress Syndrome

Interventions

PROCEDURE

Positive end-expiratory pressure titration with driving pressure control

Positive end-expiratory pressure will be tailored during a decremental maneuver (without a formal alveolar recruitment maneuver). The best positive end-expiratory pressure will be defined as the one associated with the higher respiratory system compliance, up to 20 cmH2O. Plateau pressure limit will be 30 cmH2O. If driving pressure remains elevated after optimal PEEP setting, tidal volume will be reduced to keep driving pressure below 14 cmH2O.

PROCEDURE

ARDSNet ventilatory strategy

Positive end-expiratory pressure will be set according to fixed inspired oxygen fraction values.

Sponsors & Collaborators

  • Brazilian Research In Intensive Care Network

    collaborator NETWORK

  • Hospital do Coracao

    lead OTHER

Principal Investigators

  • Israel S Maia, MSc · HCor Research Institute

  • Bruno Tomazini, MD · HCor Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-04
Primary Completion
2023-09-09
Completion
2023-09-21

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04972318 on ClinicalTrials.gov