Variable Pressure Support Trial

Summary

In 2008 a new ventilation strategy termed variable Pressure Support ventilation (PSV) was introduced, which is able to increase the variability of the respiratory pattern independent from the inspiratory effort. In experimental lung injury, variable PSV was found to improve gas exchange and decrease the inspiratory effort, while reducing alveolar edema and inflammatory infiltration compared to conventional(non-variable) PSV. Importantly, variable PSV reduced peak airway pressure and respiratory system elastance in a variability dependent manner.In addition, preliminary observations suggest that variable PSV can reduce the work of breathing and improve patient comfort, but it is not known whether this new ventilatory strategy is able to speed the weaning from mechanical ventilation.

Since variable PSV can reduce the mean pressure support, it may lead to a faster reduction of pressure support and, therefore, a shorter weaning period than conventional PSV.

The hypothesis of this study is that variable pressure support ventilation reduces the duration of mechanical ventilation to non-variable (conventional) pressure support ventilation.

Conditions

• Acute Lung Injury
• Adult Respiratory Distress Syndrome
• at Least 24 h of Controlled Mechanical Ventilation

Interventions

OTHER

Variable Ventilation

Sponsors & Collaborators

• Medical University of Vienna

  collaborator OTHER

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  collaborator OTHER

• University Hospital, Montpellier

  collaborator OTHER

• Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

  collaborator OTHER

• IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

  collaborator OTHER

• St Thomas' Hospital, London

  collaborator OTHER

• Hospital Sírio-Libânes, São Paulo, Brazil

  collaborator UNKNOWN

• Hospital Copa D'Or, Rio de Janeiro, Brazil

  collaborator UNKNOWN

• Hospital Universitari Sant Joan de Reus

  collaborator OTHER

• University of Kiel

  collaborator OTHER

• Fachkrankenhaus Coswig GmbH

  collaborator INDUSTRY

• Technische Universität Dresden

  lead OTHER

Principal Investigators

• Marcelo Gama de Abreu · Dresden University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-01-31

Primary Completion

2018-01-31

Completion

2018-01-31

Countries

• Germany

Study Locations