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Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS Patients

NCT03513809 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-03-10

No results posted yet for this study

Summary

Spontaneous breathing efforts in patients with respiratory failure connected to mechanical ventilation, has been associated with strong respiratory muscles activity. However, these mechanisms may will be present in patients with acute lung deseases who are breathing with no ventilatory support.

We hypothesize that spontaneous breathing during acute respiratory failure could induced lung inflammation and worsen lung damage. Hereby, the connection to a ventilatory support tool, may protect the lungs from spontaneous ventilation-induced lung injury.

To test our hypothesis, our aim is to determine the effects of spontaneous breathing in acute respiratory failure patients, on lung injury distribution; and to determine whether early controlled mechanical ventilation can avoid these deleterious effects by improving air distribution.

Conditions

  • Acute Hypoxemic Respiratory Failure
  • Acute Respiratory Distress Syndrome

Interventions

DEVICE

Thoracic electrical impedance tomography

Non invasive, radiation-free, bedside monitoring tool for distribution of pulmonary ventilation.

Sponsors & Collaborators

  • Comisión Nacional de Investigación Científica y Tecnológica

    collaborator OTHER_GOV

  • Pontificia Universidad Catolica de Chile

    lead OTHER

Principal Investigators

  • Jaime A Retamal · Pontificia Universidad Catolica de Chile

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-08
Primary Completion
2021-03-21
Completion
2021-03-31

Countries

  • Chile

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03513809 on ClinicalTrials.gov