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Cognitive Function and Fatigue After Brain Abscess

NCT04938362 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-07-04

No results posted yet for this study

Summary

Brain abscess is a focal bacterial or fungal infection of the brain. Treatment is neurosurgical drainage of pus followed by long-term antibiotic treatment. In spite of successful treatment of the infection, long-term cognitive problems or mental fatigue may ensue. The reason for this dysfunction may be a continuing inflammatory state or damage to brain tissue caused by the abscess. The investigators will evaluate these possibilities with the use of \[18F\]deoxyglucose-positron emission tomography (FDG-PET) and electroencephalography (EEG) in patients who have been treated for brain abscess and who experience cognitive problems and/or fatigue. FDG-PET may identify both inflammation and altered neuronal activity (the latter indicating damage to brain tissue), and EEG may identify altered neuronal activity, including changes in neuronal network activity.

Conditions

  • Brain Abscess
  • Fatigue
  • Cognitive Dysfunction

Interventions

OTHER

FDG-PET

\[18F\]Deoxyglucose-positron emission tomography at 0-10 years after brain abscess

OTHER

EEG

Electroencephalography (EEG) at 0-10 years after brain abscess

Sponsors & Collaborators

  • Oslo University Hospital

    collaborator OTHER

  • Sunnaas Rehabilitation Hospital

    collaborator OTHER

  • University of Oslo

    lead OTHER

Principal Investigators

  • Bjørnar Hassel, MD, PhD · University of Oslo

  • Daniel Dahlberg, MD, PhD · Oslo University Hospital

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-01
Primary Completion
2030-12-31
Completion
2030-12-31

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04938362 on ClinicalTrials.gov