Diabetic Nephropathy in People With Diabetes. Prevalence and Predictive Factors

Summary

a prospective, observational, multi-center study with a cohort of 300 patients with Type 2 diabetes and macroalbuminuria. Prospectively we will collect kidney biopsies and analyse the transciptome of the kidney tissue and other biomarkers from blood, faeces, urine, proteomic- and metabolomic profiles and DNA-variants. Thereby we hope to be able to discover molecular and clinical profiles, that can help us in the diagnosis of DKD, and to identify different risks of progression that can benefit from different forms of personalized treatment.

Conditions

• Chronic Kidney Diseases
• Albuminuria
• Diabetic Kidney Disease
• Diabetic Nephropathies
• Diabetes type2
• Molecular Sequence Variation
• Kidney Biopsy

Interventions

PROCEDURE

Kidney Biopsy

Harvesting of kidney tissue from people with type 2 diabetes and albuminuria for subsequent analysis

Sponsors & Collaborators

• Rigshospitalet, Denmark

  collaborator OTHER

• Hillerod Hospital, Denmark

  collaborator OTHER

• Zealand University Hospital

  collaborator OTHER

• Holbaek Sygehus

  collaborator OTHER

• Slagelse Sygehus

  collaborator OTHER

• Nykøbing Falster County Hospital

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• The Novo Nordisk Foundation Center for Basic Metabolic Research

  collaborator OTHER

• Novo Nordisk A/S

  collaborator INDUSTRY

• Gubra ApS

  collaborator UNKNOWN

• Odense University Hospital

  collaborator OTHER

• Aalborg University Hospital

  collaborator OTHER

• Gødstrup Hospital

  collaborator OTHER

• Steno Diabetes Center Copenhagen

  collaborator OTHER

• Steno Diabetes Center Sjaelland

  collaborator OTHER_GOV

• Steno Diabetes Center Nordjylland

  collaborator OTHER

• Michigan Kidney Translational Medical Center

  collaborator UNKNOWN

• Herlev Hospital

  lead OTHER

Principal Investigators

• Frederik Persson, MD, PhD · Steno Diabetes Center Copenhagen

Eligibility

Min Age

18 Years

Max Age

120 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-08-10

Primary Completion

2043-12-31

Completion

2043-12-31

Countries

• Denmark

Study Locations