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Neurovascular Coupling and Autonomic Neuropathy in Type 2 Diabetes

NCT04625751 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2024-04-12

No results posted yet for this study

Summary

Diabetes is a growing global health care challenge. Diabetes patients may also suffer from cardiovascular autonomic neuropathy (CAN) which may affect cerebral perfusion. The main purpose of this project is to investigate the association between CAN and disturbances in the neurovascular coupling in type 2 diabetes patients. Moreover, the purpose is also to investigate coherence between CAN and the enteric nervous system. Finally, this project aims at delineating microstructural changes in the brain tissues as a consequence of CAN.

Conditions

Interventions

OTHER

CO2-enriched air

To assess cardiovascular reactivity

OTHER

Meal response test

Meal response test to assess changes in splanchnic blood flow.

Sponsors & Collaborators

  • Steno Diabetes Center Copenhagen

    collaborator OTHER

  • Hartwig R. Siebner

    lead OTHER

Principal Investigators

  • Hartwig R. Siebner, MD, Prof · Danish Research Centre for Magnetic Resonance

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-07
Primary Completion
2024-12-31
Completion
2025-07-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04625751 on ClinicalTrials.gov