Study of Offspring of Women With Type 1 Diabetes

Summary

There is an increasing trend in the society for developing obesity, type 2 diabetes and cardiovascular diseases. It is therefore important to identify the risk factors behind this tendency. Recent studies have shown that exposure to high blood sugar levels in pregnancy (as in mothers with type 1 diabetes) may play a role in the development of obesity, type 2 diabetes and cardiovascular diseases later in life for the children. Some studies suggest that high blood sugar levels during pregnancy can also affects cognitive function as well as growth and development of puberty. The mechanisms behind this are not sufficiently clarified yet.

In the period 1993-1999, pregnant women with type 1 diabetes in Denmark were followed and information about the course of pregnancy was collected, including the long-term blood sugar level during pregnancy and the children's' condition at birth. The unique opportunities in Denmark to identify and follow the children of these mothers and the possibility to select a comparison group of children of non-diabetic mothers gives a unique opportunity to examine the children of mothers with type 1 diabetes and accurately investigate the effect of blood sugar levels in pregnancy on conditions later in life.

There has not previously been made any study of this size and it is the investigators hope to be able to quantify the effect of blood sugar level during pregnancy on outcomes later in life. This will potentially give the possibility to detect individuals at risk for cardiovascular diseases earlier and to improve prevention targets in children of mothers with diabetes.

Conditions

• Type 1 Diabetes

Sponsors & Collaborators

• University of Copenhagen

  collaborator OTHER

• Department of Gynaecology and Obstetrics, Rigshospitalet, Copenhagen

  collaborator UNKNOWN

• Rigshospitalet, Denmark

  collaborator OTHER

• University of Southern Denmark

  collaborator OTHER

• University of Aarhus

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Odense University Hospital

  lead OTHER

Principal Investigators

• Dorte Møller Jensen, Associated Professor, PhD · Odense University Hospital

Eligibility

Min Age

13 Years

Max Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-04-30

Primary Completion

2017-11-30

Completion

2017-12-31

Countries

• Denmark

Study Locations