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PEEP in Patients With Acute Respiratory Failure

NCT04912960 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2025-04-20

No results posted yet for this study

Summary

Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support. In 1975, several investigators published the effects of PEEP in 15 mechanically ventilated patients with acute respiratory failure (ARF) supported by mechanical ventilation. FiO2 ranged between 21% to 75% and the tidal volume between 13 to 15 mL/kg. PEEP was increased in 3 cmH2O steps until cardiac output fell. The aim was to identify the "optimum" PEEP level. "Best" PEEP was associated simultaneously with the best static compliance of the respiratory system, the greatest oxygen transport, and the lowest dead space fraction. That study established the basis for the use of PEEP in patients with ARF worldwide. Although currently patients with ARF are ventilated with much lower tidal volumes, that study has never been validated. It is unknow whether their findings are currently valid, generalizable, and reproducible.

Conditions

  • Acute Respiratory Failure With Hypoxia

Interventions

DEVICE

Mechanical ventilation

Optimum PEEP

Sponsors & Collaborators

  • Jesus Villar

    lead OTHER

Principal Investigators

  • Jesús Villar, MD · Hospital Universitario Dr. Negrin

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-10
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04912960 on ClinicalTrials.gov