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Optimal Level of PEEP in Protective One-lung Ventilation

NCT03856918 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 142

Last updated 2022-04-18

No results posted yet for this study

Summary

Protective ventilation strategy has been widely applied in the field of thoracic surgery requiring one-lung ventilation to reduce postoperative pulmonary complications. Low tidal volume, positive end-expiratory pressure (PEEP), and intermittent recruitment maneuver are key components of protective ventilation strategy. Recent evidence suggests that a tidal volume of 4-5 ml/kg should be applied during protective one-lung ventilation. However, optimal level of PEEP is still unclear. This study aims to investigate optimal level of PEEP to minimize postoperative atelectasis by comparing modified lung ultrasound score in patients applied protective one-lung ventilation using PEEP of 3, 6, or 9 cm of water during thoracic surgery.

Conditions

  • Video-assisted Thoracic Surgery
  • Postoperative Atelectasis
  • Positive End-expiratory Pressure

Interventions

PROCEDURE

PEEP 3 cm of water

PEEP of 3 cm of water will be applied during one-lung ventilation.

PROCEDURE

PEEP 6 cm of water

PEEP of 6 cm of water will be applied during one-lung ventilation.

PROCEDURE

PEEP 9 cm of water

PEEP of 9 cm of water will be applied during one-lung ventilation.

Sponsors & Collaborators

  • Seoul National University Hospital

    lead OTHER

Principal Investigators

  • Jae-Hyon Bahk, MD,PhD · Seoul National University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-28
Primary Completion
2020-02-11
Completion
2021-02-28

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03856918 on ClinicalTrials.gov