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Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

NCT05442073 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 18

Last updated 2022-07-01

No results posted yet for this study

Summary

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

Conditions

  • ARDS, Human
  • PEEP, Occult
  • Esophageal and Pleural Pressure

Interventions

OTHER

PEEP adjustment

adjusting PEEP about 3-5cmH2O (increase or decrease)

Sponsors & Collaborators

  • Peking Union Medical College Hospital

    lead OTHER

Principal Investigators

  • Shuyang Zhang, MD · Peking Union Medical College Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2022-05-31
Completion
2022-06-29

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05442073 on ClinicalTrials.gov