Vfib by ECG or Echo During Cardiac Arrest

Summary

The goal of this study is to measure survival rates associated with patients presenting in cardiac arrest based on their electrocardiographic rhythm and their echocardiographic rhythm. Electrocardiographic rhythm is defined as the rhythm on the ECG and echocardiographic rhythm is the rhythm visualized on bedside ultrasound. Specifically, we will categorize patients based on identical rhythms and dichotomous rhythms with an interest in outcomes in the patient group where their echocardiographic and electrographic rhythms do not match. This is important as current ACLS protocols use electrocardiographic rhythms to determine therapy but limited research implies that therapeutic decisions based on echocardiographic rhythm may produce increased survival.

This study will occur during emergency department resuscitation of patients presenting in cardiac arrest. Patients presenting to the emergency department after cardiac arrest will undergo standard resuscitation based on ACLS protocols. Ultrasound imaging will be performed as soon as possible after the patient arrives and digitally recorded, as is currently the standard of care at the institute. Simultaneous recording of the ECG rhythm strip will occur as well. This will be repeated for as many pauses in CPR as is warranted.

Each site will record data based on the Utstein nomenclature including patient demographics, arrest details and survival outcomes. Ultrasound images and ECG recordings will be de-identified and submitted to a central database. Data will be uploaded into a centralized database. Statistical analysis will analyze outcomes based on echocardiographic and sonographic findings. Our aim is to measure the survival benefit of treating out of hospital cardiac arrest using echocardiographic rhythm instead of electrocardiographic rhythm.

Conditions

• Cardiac Arrest

Interventions

DIAGNOSTIC_TEST

Echocardiography

Patients presenting in cardiac arrest will undergo echocardiography as is the standard of care at their institution

DIAGNOSTIC_TEST

Electrocardiogram (ECG)

Patients presenting in cardiac arrest will undergo an electrocardiogram (ECG) as is the standard of care at their institution

Sponsors & Collaborators

• Temple University

  collaborator OTHER

• Stony Brook University

  collaborator OTHER

• University of Ottawa

  collaborator OTHER

• ChristianaCare

  collaborator OTHER

• Boston Medical Center

  collaborator OTHER

• Dartmouth College

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• University of Rochester

  collaborator OTHER

• Baystate Medical Center

  collaborator OTHER

• Medical College of Wisconsin

  collaborator OTHER

• University of Pennsylvania

  collaborator OTHER

• Prisma Health-Midlands

  collaborator OTHER

• Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

  collaborator OTHER

• Staten Island University Hospital

  collaborator OTHER

• State University of New York - Upstate Medical University

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Kaweah Delta Health Care District

  collaborator OTHER

• SBH Health System

  collaborator OTHER

• Yale University

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• The University of Texas at San Antonio

  collaborator OTHER

• Wake Forest University Health Sciences

  collaborator OTHER

• University of Arkansas

  collaborator OTHER

• Valleywise Health

  collaborator OTHER

• Kendall Healthcare Group, Ltd.

  collaborator INDUSTRY

• Truman Medical Center

  collaborator OTHER

• Oregon Health and Science University

  collaborator OTHER

• Vassar Brothers Medical Center

  collaborator OTHER

• Brookdale University Hospital Medical Center

  collaborator OTHER

• University of Kansas Medical Center

  collaborator OTHER

• University of Maine

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• Duke University

  collaborator OTHER

• University at Buffalo

  collaborator OTHER

• North Shore University Hospital

  collaborator OTHER

• Hartford Hospital

  collaborator OTHER

• Louisiana State University Health Sciences Center in New Orleans

  collaborator OTHER

• University of Florida

  collaborator OTHER

• University of Maryland

  collaborator OTHER

• Sutter Medical Foundation

  collaborator OTHER

• Arizona School of Health Sciences

  collaborator OTHER

• Virginia Commonwealth University

  collaborator OTHER

• Romolo Gaspari

  lead OTHER

Principal Investigators

• Romolo Gaspari, MD, PhD · UMass Medical School

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-09-15

Primary Completion

2024-12-31

Completion

2025-01-01

Countries

• United States

Study Locations