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Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy

NCT04065893 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 65

Last updated 2021-11-15

No results posted yet for this study

Summary

Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure. Most effective mortality reduction was seen with a BiV pacing above 98%.

Reduced BiV pacing is a common phenomenon with potential impact on CRT-response and pts' prognosis. Frequent ventricular ectopy may be associated with attenuated benefit from CRT. The investigators sought to systematically assess the effect of ventricular arrhythmia treatment on BiV pacing.

Conditions

  • Systolic Heart Failure
  • Ventricular Premature Complexes
  • Ventricular Tachycardia
  • Cardiac Resynchronization Therapy
  • Reduced Biventricular Pacing

Interventions

PROCEDURE

Catheter ablation of ventricular arrhythmia

PVC or VT ablation

DRUG

Intensified medical therapy

Dosage increase / new onset of Betablocker / medical antiarrhythmic medication according to guideline and clinical practice

Sponsors & Collaborators

  • Universitätsklinikum Köln

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2021-08-01
Completion
2021-08-01

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04065893 on ClinicalTrials.gov