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POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium

NCT04899635 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-06-18

No results posted yet for this study

Summary

To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.

Conditions

  • Heart Failure
  • Fatigue; Muscle, Heart
  • Myocardial Dysfunction
  • Exhaustion; Heart

Interventions

OTHER

In-vitro contractile fatigue protocol

Using contractility assays for muscle slices or the work-loop assay for isolated heart cells, the tissue preparation will undergo a series of contraction and relaxation under varying levels of preload, afterload, stimulation frequency and under other experimental conditions such as drug-induced inotropism.

Sponsors & Collaborators

  • Coventry University

    collaborator OTHER

  • University Hospitals Coventry and Warwickshire NHS Trust

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-03
Primary Completion
2025-04-30
Completion
2025-04-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04899635 on ClinicalTrials.gov