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Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease

NCT03660969 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 797

Last updated 2025-04-22

No results posted yet for this study

Summary

Visits to the emergency department (ED) for chest pain are extremely common and require a safe, rapid and efficacious treatment algorithm to exclude a possible AMI. These diagnostic algorithms are partly based on an important laboratory value, which showed growing utility in the diagnostic and prognostic of many cardiovascular diseases in the last years : cardiac troponin.

However, some patients with muscle disease often present with unexplained elevated high-sensitive cardiac Troponin T (hs-cTnT) levels in the absence of cardiac disease. The investigators aim at the characterization of the behaviour of this biomarker and its alternative (high-sensitive cardiac Troponin I), which will have important clinical implications on patients management.

Conditions

  • Myopathy
  • Muscle Weakness
  • Muscle Damage
  • Muscle Spasticity
  • Muscle Cramp
  • Muscle Injury
  • Muscle Soreness
  • Muscle Atrophy

Sponsors & Collaborators

  • Cantonal Hospital of Aarau, Switzerland

    collaborator OTHER

  • Medical University Innsbruck

    collaborator OTHER

  • University Hospital, Zürich

    collaborator OTHER

  • Insel Gruppe AG, University Hospital Bern

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Christian Mueller, MD · University Hospital, Basel, Switzerland

  • Angelika Hammerer, MD · Canton Hospital Aarau

  • Julia Wanschitz, MD · Medical University Innsbruck

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Austria
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03660969 on ClinicalTrials.gov