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Quantitative Stress Echocardiography to Diagnose Myocardial Ischaemia

NCT03659526 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 390

Last updated 2018-09-06

No results posted yet for this study

Summary

Patients with chest pain on exertion need a reliable non-invasive test to identify if they have inducible myocardial ischaemia. This would reduce the use of diagnostic coronary arteriography, avoid its risks and costs, and guide clinical decisions. Conventional stress echocardiography has poor reproducibility because it relies on qualitative and subjective interpretation. Quantitative approaches based on precise and reliable measurements of myocardial velocity, strain, strain rate and global longitudinal strain have been shown to be able to accurately diagnose myocardial ischaemia. A more accurate test using myocardial velocity imaging was not implemented by ultrasound vendors although it provided an objective measurement of myocardial functional reserve on a continuous scale from normality to severe ischaemia.

The investigators propose an original approach to create a diagnostic software tool that can be used in routine clinical practice. The investigators will extract and compare quantitative data obtained through myocardial velocity imaging and speckle tracking in subjects who undergo dobutamine stress echocardiography.

The data will be analysed using advanced computational mathematics including multiple kernel learning and joint statistics applied to multivariate data across multiple dimensions (including velocity, strain and strain rate traces). This approach will be validated against quantitative coronary arteriography and fractional flow reserve. The results will be displayed as parametric images and placed into a reporting tool. The output will determine the presence and severity of myocardial ischaemia. These new tools will have the capacity for iterative learning so that the precision of the diagnostic conclusions can be continuously refined.

Conditions

  • Ischemia, Myocardial

Interventions

DIAGNOSTIC_TEST

Deformation imaging

Deformation parameters derived using myocardial velocity imaging or speckle tracking

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    collaborator OTHER

  • Universitat Pompeu Fabra

    collaborator OTHER

  • Hull University Teaching Hospitals NHS Trust

    collaborator OTHER_GOV

  • Danderyd Hospital

    collaborator OTHER

  • University Hospital of Wales

    lead OTHER

Principal Investigators

  • Alan G Fraser · University Hospital Wales

Eligibility

Min Age
20 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-21
Primary Completion
2020-10-31
Completion
2021-10-31

Countries

  • Belgium
  • Sweden
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03659526 on ClinicalTrials.gov