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Exercise-induced Changes in Cardiac Function & Morphology

NCT01179802 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2011-02-15

No results posted yet for this study

Summary

Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity. However, little is known about the effects of intense endurance stress on the heart. According to current knowledge repeated exposure to strenuous endurance activity may lead to minor but possibly irreversible damage to the heart with resultant scarring of the heart's muscle.

Within this study we attempt to find out by different analytical methods - in particular magnetic resonance imaging (MRI) and ultrasound of the heart - to what extent the heart muscle is affected by an intense endurance exercise, i.e. the "Jungfrau-Marathon", and which changes can possibly be found. Due to repeated measurements we will obtain further information on the short-term course of possible changes.

Hypotheses: A single bout of prolonged strenuous exercise (PSE) leads to transient alteration in cardiac function accompanied by the appearance of biomarkers for myocardial damage.

Conditions

  • Myocardial Ischemia
  • Exercise
  • Myocardial Contraction
  • Myocardial Stunning
  • Heart Failure

Interventions

OTHER

Strenuous Endurance exercise

"Jungfraumarathon": Mountain-Marathon with a length of 42km and a altitude-difference of approximately 1830meters.

Sponsors & Collaborators

  • Federal Office of Sports, Switzerland

    collaborator OTHER_GOV

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Michael Ith, PhD, PhD/MD · Dept. of Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern

  • Christoph Stettler, MD · Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2010-10-31
Completion
2010-10-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01179802 on ClinicalTrials.gov