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Adipose Tissue Inflammation in HFpEF

NCT04886713 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2021-05-14

No results posted yet for this study

Summary

To evaluate the role of adipose tissue inflammation in patients with heart failure with preserved ejection fraction (HFpEF). Patients undergoing coronary artery bypass grafting with HFpEF and without heart failure will be included in this prospective study. Epicardial, paracardial, paraaortic/paravascular, subcutaneous adipose tissue samples as well as myocardial tissue will be harvested during cardiac surgery. Inflammatory patterns of these tissues and their relation to circulating markers will be investigated.

Conditions

Interventions

DIAGNOSTIC_TEST

Adipose and myocardial tissue sampling

After median sternotomy tissue samples will be collected from the epicardial space, the abdominal wall and the myocardium.

DIAGNOSTIC_TEST

Cardiac magnetic resonance imaging

Magnetic resonance imaging will be performed at 1.5 Tesla ('Intera', Philips Medical Systems, Best, The Netherlands). All subjects will be examined in the supine position with initial anatomy scans to cover the thorax to the first sacral vertebrae. The magnetic resonance imaging protocol is summarized in Figure 4. The following imaging parameters will be acquired: * Biventricular end-diastolic and end-systolic volume, ejection fraction, stroke volume * Biventricular mass, wall thickness * T1 mapping; native and \> 10 minutes post contrast injection as an estimate of left ventricular diffuse fibrosis and extracellular volume * Late enhancement for detection of regional fibrosis and scar * Myocardial feature tracking for analysis of deformation/motion * Epicardial fat volume

DIAGNOSTIC_TEST

Cardiopulmonary exercise testing

After completion of a regular cardiac rehabilitation program patients are scheduled to undergo their discharge examination at 3 to 4 weeks after the operation in order to be functionally characterized. Cardiopulmonary exercise testing will be performed, if possible by patients condition, on a mechanically braked bicycle ergometer and respiratory gas exchange analysis via a mouthpiece or facemask.

Sponsors & Collaborators

  • Heart Center Leipzig - University Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-01
Primary Completion
2021-12-31
Completion
2022-03-15

Countries

  • Germany

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04886713 on ClinicalTrials.gov