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Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis

NCT04856410 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2025-10-10

No results posted yet for this study

Summary

This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and functional brain changes in general, and hippocampal plasticity more specifically relative to the shorter 6-month and 2-month missions.

Conditions

  • Brain Structure
  • Cognitive Performance

Interventions

OTHER

Spaceflight

Exposure to the spaceflight environment on the International Space Station for 2, 6, or 12 months.

OTHER

Controls

No intervention

Sponsors & Collaborators

  • National Aeronautics and Space Administration (NASA)

    collaborator FED

  • DLR German Aerospace Center

    collaborator OTHER

  • Charite University, Berlin, Germany

    collaborator OTHER

  • University of Pennsylvania

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-08-01
Primary Completion
2027-06-30
Completion
2028-06-30

Countries

  • United States
  • Germany

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04856410 on ClinicalTrials.gov