Effects of Parabolic Flight on Spatial Cognition and Hippocampal Plasticity

Summary

The main objective of this experiment is to assess the impact of parabolic flight on (1) spatial memory and orientation, (2) the changes in brain structure and function, and particularly the hippocampal formation, and (3) biochemical markers of stress and neuroplasticity.

A preliminary study will be performed with the aims (1) to test during weightlessness hardware used to administer visuo-spatial testing and (2) to determine the optimal body posture for testing under microgravity conditions (i.e. body posture for which change in visuo-spatial testing induced by weightlessness is maximal).

The main criteria are:

* Structural and functional changes of brain evaluated by fMRI;
* Cognitive performance, and specifically spatial cognition using a series computer-based tasks.
* Key neurotrophins determined in venous blood samples The criteria used in the preliminary experiment is visuo-spatial performance evaluated with a computer-based test assessing spatial cognition.

The investigators hypothesize that hippocampal structure and function, and particularly the dentate gyrus, will be altered after parabolic flight compared to ground based controls. Specifically, the 3 tested hypotheses are:

* Parabolic flight induces changes in hippocampal structure;
* Weightlessness induces changes in cognitive performance, and specifically spatial cognition;
* There is a correlation between changes in hippocampal structure and changes in visuo-spatial memory performance.
* There is a correlation between changes in hippocampal structure and changes in key neurotrophins.

The hypothesis tested during the preliminary experiment is that body posture affects the changes in spatial cognition performance.

Conditions

• Healthy Volunteers

Interventions

OTHER

Assess the impact of parabolic flight

MRI testing will be performed using a 3T MRI facility in Bordeaux close to Novespace (CHU Pellegrin). Spatial cognition will be assessed using a battery of in-house virtual paradigms General cognitive performance testing will include a wide range of cognitive functions, and particularly executive control using the Cognition Battery Mental status will be assessed on a tablet computer using a visual analogue scale Vigilant attention will be determined using the 3-min Psychomotor Vigilance Test (PVT) Blood samples (5 mL per collection) will be collected prior to neuroimaging by venepuncture

Sponsors & Collaborators

• Novespace

  collaborator INDUSTRY

• University Hospital, Caen

  lead OTHER

Principal Investigators

• Pierre DP Denise, PhD · CHU CAEN

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

67 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-03-31

Primary Completion

2019-03-31

Completion

2019-09-30

Countries

• France

Study Locations