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Endocrine Disrupting Chemical Exposure and Testicular Cancer

NCT04848545 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 700

Last updated 2021-04-21

No results posted yet for this study

Summary

DISRUPT is a Danish nested case-control study that is currently being conducted to explore the impact of prenatal exposure to endocrine disrupting chemicals on testicular cancer risk (including histological sub-groups) with emphasis on the analysis of exposure mixtures. Pregnant mothers provided serum and amniotic fluid at recruitment up to 50 years ago. By registry linkage within highly reliable national population and disease registries cancer cases and matched controls will be identified. Levels of EDCs including DDT, DDE and other organochlorine pesticides, PCBs, PBDEs, PFAS, phthalates and triclosan will be quantified in cases whose sons develop testicular cancer during 40 year follow up and compared to controls.

Conditions

  • Testicular Cancer

Interventions

OTHER

Observational

Prenatal maternal exposure to endocrine disrupting chemicals

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Anders Juul, PhD, MD · Vækst og Reproduktion, Rigshospitalet

Eligibility

Min Age
15 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-06-01
Primary Completion
2028-12-31
Completion
2030-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04848545 on ClinicalTrials.gov