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Detection of Thyrotrophin Receptor in Human Myometrium

NCT01348191 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2013-05-24

No results posted yet for this study

Summary

It has been recognized for many decades that high thyrotrophin (TSH) levels in pregnant women are associated with poor obstetric outcome. Also, there is evidence that high TSH is related to fetal position at term, including breech which in turn is associated with obstetric complications.

However, the mechanism behind remains to be elucidated.

The current project is of basic-fundamental nature. It is used to better understand basis physiological processes. As in many other studies of similar basic nature, few numbers are always included.

If a TSH receptor will be detected, future randomized controlled trials (RCT) might be worthwhile with large numbers of women who will be treated with thyroxine to possibly prevent abnormal fetal position during normal pregnancy.

The aim of the current study is to evaluate whether a TSH receptor can be demonstrated in human myometrium. If so, the pathophysiology of high TSH in relation to obstetric outcome will become more clear. Furthermore, the aim is to test the myometrium in vitro for its relaxation and contractility and for the conductance of electropotentials.

Conditions

  • Thyrothrophin Receptor in Myometrium Tissue

Interventions

PROCEDURE

Myometrial biopsy

At caesarean section, after birth of the baby but before closure of the uterus, a biopsy from the upper lip of the incision in the lower uterine segment will be taken. This biopsy will measure approximately 2x50mm.

Sponsors & Collaborators

  • Stichting PAMM

    collaborator UNKNOWN

  • Tilburg University

    collaborator OTHER

  • Erasmus Medical Center

    collaborator OTHER

  • Eindhoven University of Technology

    collaborator OTHER

  • Catharina Ziekenhuis Eindhoven

    lead OTHER

Principal Investigators

  • simone M Kuppens, MD,PhD · Catharina-ziekenhuis, Eindhoven, the Netherlands

  • Victor J Pop, MD,PhD,Prof · University of Tilburg, Department of Medical and Neuropsychology

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-11-30
Primary Completion
2012-09-30
Completion
2013-01-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01348191 on ClinicalTrials.gov