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Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy

NCT01335802 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 113

Last updated 2020-03-18

No results posted yet for this study

Summary

Studies have demonstrated a relationship between subclinical hypothyroidism and obstetrics complications like preterm delivery, pre-eclampsia, placental abruption and stillbirth. Subclinical hypothyroidism and positive thyroperoxidase antibodies (TPOab) may increase the risk of early spontaneous abortion before 12 weeks of gestation. But there is not a consensus if the prevalence of TPOab should be treated before and during pregnancy when the level of thyroid-stimulating hormone (TSH) is normal.

Thyroid hormones are regulators of the mitochondrial activity and our research group has previously shown that subclinical hypothyroidism affects mitochondrial activity.

The hypothesis:

Subclinical hypothyroidism causes early spontaneous abortion and or complications in pregnancy like pre-eclampsia because of mitochondrial dysfunction

Conditions

  • Abortion, Spontaneous
  • Pregnancy Complications
  • Subclinical Hypothyroidism

Interventions

GENETIC

Genetic counseling

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Naestved Hospital

    lead OTHER

Principal Investigators

  • Jan Kvetny, MD, DMSc · Department of Internal Medicine & Faculty of Health Sciences, University of Copenhagen

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2015-09-30
Completion
2016-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01335802 on ClinicalTrials.gov