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Evaluation of the Autonomic Nervous System in Patients Undergoing Esophagectomy for Cancer

NCT04835987 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2023-11-24

No results posted yet for this study

Summary

Esophageal surgery is a complex surgery, with high post-operative morbidity and mortality. The incidence of complications associated with esophagectomy varies from 17% to 74%, in the literature. A section of vagus nerves is conventionally performed during esophagectomy for cancer, because of oncological margins. The vagus nerve is responsible for the parasympathetic innervation at the gastrointestinal level, but also at the cardiac and pulmonary level. The post-operative morbidity of these procedures could be linked in part to the bilateral section of the vagus nerves, because of their impact on the autonomous regulation of this vital functions. The main objective of the study is to find a modification of the sympathomimetic balance pre and post operatively, in patients undergoing esophagectomy.

Conditions

  • Esophageal Cancer

Interventions

DIAGNOSTIC_TEST

Holter ECG

Measurement of the modification of the sympathomimetic balance

BEHAVIORAL

Questionary

Lifestyle questionary (time spent in front of television, physical activity)

DIAGNOSTIC_TEST

Pupillometry

Monitoring of nociception and autonomic nervous system by pupillometry in intraoperative.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • EVE HUART, MD · CHU ST ETIENNE

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-31
Primary Completion
2024-03-31
Completion
2024-09-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04835987 on ClinicalTrials.gov