Esophagectomy in Middle and Lower Thoracic Esophageal Cancer Patients Through Left Versus Right Transthoracic Approach

Summary

Esophageal carcinoma is an aggressive malignant disease with poor prognosis. Surgical resection remains the most effective method for this malignancy. Although different approaches have been studied for the surgical resection of thoracic esophageal cancer, little evidence has been achieved due to lack of large scale multicenter randomized trials with regard to this issue: whether left transthoracic approach or right transthoracic approach is the optimal surgical approach for treating middle and lower thoracic esophageal cancer without upper mediastinal lymph node metastasis. The purpose of this study is to compare the postoperative local recurrence rate and long-term outcome of esophagectomy through left and right transthoracic approach in the middle and lower thoracic esophageal cancer patients without preoperative upper mediastinal lymph node metastasis.

Conditions

• Esophageal Cancer

Interventions

PROCEDURE

Left thoracotomy

Transthoracic approach is the surgical procedure including the open and minimally invasive thoracotomy.

PROCEDURE

Right thoracotomy

Transthoracic approach is the surgical procedure including the open and minimally invasive thoracotomy.

Sponsors & Collaborators

• Peking University Cancer Hospital & Institute

  collaborator OTHER

• Henan Cancer Hospital

  collaborator OTHER_GOV

• Hebei Medical University Fourth Hospital

  collaborator OTHER

• Harbin Medical University

  collaborator OTHER

• Liaoning Cancer Hospital & Institute

  collaborator OTHER

• Hunan Cancer Hospital

  collaborator OTHER

• Sun Yat-sen University

  collaborator OTHER

• Zhejiang Cancer Hospital

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• Chinese Academy of Medical Sciences

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2017-12-31

Completion

2019-12-31

Countries

• China

Study Locations