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Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer

NCT00047112 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 195

Last updated 2020-03-30

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy with radiation therapy before surgery may shrink the tumor so it can be removed during surgery. It is not yet known if surgery is more effective with or without radiation therapy and chemotherapy in treating esophageal cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of surgery with or without radiation therapy and chemotherapy in treating patients who have esophageal cancer.

Conditions

  • Esophageal Cancer

Interventions

DRUG

cisplatin

DRUG

fluorouracil

PROCEDURE

conventional surgery

PROCEDURE

neoadjuvant therapy

RADIATION

radiation therapy

Sponsors & Collaborators

  • GERCOR - Multidisciplinary Oncology Cooperative Group

    collaborator OTHER

  • European Organisation for Research and Treatment of Cancer - EORTC

    collaborator NETWORK

  • UNICANCER

    collaborator OTHER

  • Societe Francaise de Radiotherapie Oncologique

    collaborator OTHER

  • Federation Francophone de Cancerologie Digestive

    lead OTHER

Principal Investigators

  • J. P. Triboulet · Centre Hospitalier Regional et Universitaire de Lille

  • Jean-Francois Seitz, MD · Institut Paoli-Calmettes

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Max Age
74 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-05-31
Primary Completion
2010-09-30
Completion
2010-09-30

Countries

  • Belgium
  • France
  • Germany
  • Netherlands

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00047112 on ClinicalTrials.gov