Esophageal Cancer Risk Registry

Summary

The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.

Conditions

• Esophageal Cancer
• Gastroesophageal Reflux Disease (GERD)
• Esophageal Diseases
• Hiatal Hernia
• Esophageal Achalasia

Interventions

PROCEDURE

Survey of client health, personal habits, family history

A questionnaire is administered at the time of consent.

PROCEDURE

Blood specimen for non-DNA and DNA parts

Blood specimen is collected prior to surgery or at the time of scheduled routine surgical procedure(s), and at the time of routine follow-up visits

PROCEDURE

Biopsy of esophageal/stomach tissue, lymph nodes, tumor

Tissue from the biopsies is collected intraoperatively.

PROCEDURE

Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies

Tissue from the biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushings are collected intraoperatively.

Sponsors & Collaborators

• National Institutes of Health (NIH)

  collaborator NIH

• National Cancer Institute (NCI)

  collaborator NIH

• University of Pittsburgh

  lead OTHER

Principal Investigators

• James D. Luketich, MD · Department of Cardiothoracic Surgery

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1999-06-30

Primary Completion

2050-12-31

Completion

2050-12-31

Countries

• United States

Study Locations