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Decompensation of Cirrhosis and Iron Metabolism

NCT04807023 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-07-19

No results posted yet for this study

Summary

Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels. In line with the major role of the liver in iron homeostasis, links between iron metabolism and acute on chronic liver failure have been highlighted. Nevertheless, due to the difficulty of accurately assessing iron metabolism in this situation, therapeutic intervention on iron metabolism in this setting is currently not codified.

A better understanding of these mechanisms is therefore essential, in particular by characterizing the impact of exposure to non-transferrin-bound iron in acute on chronic liver failure on short-term mortality.

Overall, a better understanding of the physiopathological mechanisms of iron should allow to optimize the martial balance in this condition and also improve therapeutic approaches.

Conditions

  • Cirrhosis

Interventions

BIOLOGICAL

blood sampling

blood sampling

Sponsors & Collaborators

  • Rennes University Hospital

    lead OTHER

Principal Investigators

  • Giguet Baptiste · CHU Rennes

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-17
Primary Completion
2022-05-31
Completion
2022-11-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04807023 on ClinicalTrials.gov